Throughout the last couple of years, Artificial Intelligence (AI) has come under consideration as a revolutionizer of numerous sectors in which the non-profit sector is involved is not an exception. AI intervention can be applied to the non-profit techniques in a way that this paper seeks to explain the extent of the success that can be realized. It discusses AI’s role in the non-profit organizations and pinpoints technologies like data analysis, AI-based fundraising solutions, program assessment, and chatbots to engage the donors. The paper also reviews general issues associated with the application of AI solutions including inadequate funds, dearth of specialists in AI and data privacy issues, and come up with measures to mitigate these challenges. It also elaborates on the evaluation indicators of the degree of AI impact in non-profits such as, efficiency increment indicators, fundraising indicators, changes in the programs, and indicators of stakeholders. The conclusions are that it is possible to achieve the positive impact on the function of distinctive non-profit organizations through the successful application of AI.